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Post RARP PSA level

User
Posted 10 May 2024 at 19:31

Hi Adrian56,

Great to hear you are still clear. My pre op PSA 13.8 on regular annual health check, totally asymptomatic( missed previous 2 annual health checks avoiding hospitals due to Covid….oh well…)

Staging post op pathology pT3b pNO and Gleason 4+5 ( percentage of pattern 5 was 30%).

Seminal vesicle invasion , from the pathology report:

Part A is designated "prostate and seminal vesicle and anterior bladder neck" and consists of a 75.2 gram, 6.5 cm right to left by 4.5 cm apex to base by 4.5 cm anterior to posterior prostate with attached seminal vesicles (right is 4.1 x 1.5 x 0.5 cm; left is 4.1 x 1.5 x 0.6 cm) and vasa deferentia (right is 5.5 cm in length by 0.7 cm in diameter; left is 3.7 cm in length by 0.8 cm in

Cheers Clinton

 

 

User
Posted 10 May 2024 at 19:42

Hi Chris,

Thankyou for sharing that , I am really interested in getting accurate scans to better direct radiation. What sort of scan were you having when they included your knees? What was your PSA at the time? Was this scan due to BCR after initial treatment?

Thanks Clinton

User
Posted 10 May 2024 at 20:02

Hi Clinton. I did respond to your original post but you may not have seen it. We seem to have similar journeys

User
Posted 10 May 2024 at 20:26

Originally Posted by: Online Community Member

Hi Clinton. I did respond to your original post but you may not have seen it.

Clinton has just responded to it Chris. πŸ‘

https://community.prostatecanceruk.org/posts/t30583-High-First-Post-RP-PSA-test

 

Edited by member 10 May 2024 at 20:28  | Reason: Link

User
Posted 10 May 2024 at 20:53

Originally Posted by: Online Community Member

Hi Chris,

Thankyou for sharing that , I am really interested in getting accurate scans to better direct radiation. What sort of scan were you having when they included your knees? What was your PSA at the time? Was this scan due to BCR after initial treatment?

Thanks Clinton

Clinton,click on my name and have a look at the beginning of my profile to see the journey. 

The scan that included the knees was the Gallium 68 PSMA scan and the PSA was 4.6, that was my third recurrence.

Surgery 2024.

Salvage RT to prostate bed not HT due to stricture issue ,the PSA did drop for a while so something was presumably in the bed .2017

5 SABR treatments to pelvic lymph nodes August 2022.

At this point we took advantage of private medical insurance, the NHS does have restrictions of the number of tumors they will trea.

5 SABR treatments to second pelvic lymph node plus bicalutamide May 2023.

There is research on the different tracers used in PSMA scans, my 1007 tracer didn't pick up the second tumor,but it was described as very small. Hope this helps

Thanks Chris 

User
Posted 10 May 2024 at 21:42
Thankyou Chris for your sharing your chronology detail, it certainly underlines the "journey" concept for me. All the best. Clinton
User
Posted 17 May 2024 at 07:21

Originally Posted by: Online Community Member

Thank you. I’ve recently had  PSMA PET CT scan to see if the source of the PSA level can be identified.  I’m due to discuss the results on a phone appointment with the consultant surgeon next week so I’m hoping for some answers.  

Any news yet mate?

User
Posted 31 May 2024 at 12:55

Hi everyone.  I’ve has the PET CT scan and I’ve had the phone appointment with the surgeon to discuss the results.  The scan was inconclusive but showed no “hot spots” and no evidence to suggest it’s spread but it didn’t show the source of the PSA levels.   I’ve now had 3 blood tests since my op in February and the readings have been 4.06, 3.73 and the most recent from just over a week ago was 3.68. Heading in the right direction but VERY slowly especially considering that it was at 4.9 at its highest pre op.  The surgeon is puzzled and has referred me to a urologist oncologist next week to see if he can shed some light on it.   

User
Posted 31 May 2024 at 13:01

Great news regarding no hot spots! Its certainly a mystery, but at least the readings are heading in the right direction.

I hope that they solve the mystery and that you make a full and speedy recovery.

Please keep us updated.

Edited by member 01 Jun 2024 at 21:02  | Reason: Typo

User
Posted 07 Jun 2024 at 01:55

Hi Adrian.  I went to see the urology oncologist consultant on Wednesday 5/6 to discuss the refusal of my PSA levels to drop and the PET CT scan results.   He told he that I have some prostate tissue which couldn’t be removed in the operation which is at stage 3 which will require radiotherapy to treat.  I have a planning CT scan next week and the treatment will be every day Monday - Friday for 4 weeks starting in 2-3 weeks time as well as hormone injections every 3 months for 2 years.  He was very reassuring and told me that it’s totally curable and I will be fine.

User
Posted 07 Jun 2024 at 08:09

Hello mate. Thank you very much for the update.

Presumably he confirmed that your PSMA scan was clear? ( PS: I keep getting PSMA (Prostate Specific Membrane Anti-gen) and PMAS (Police Mutual Assurance Society) mixed up. One helps save your life, the other just helps you save.😊)

Its a shame that your operation wasn't completely successful  in removing all the cancerous cells. It seems quite a common problem that cells are left behind in the prostate bed. What's not so common is for your PSA to be almost as high post op as it was pre op, and that still mystifies me. 

However, I'm so pleased that you've quickly been give a follow up treatment plan and hope wish you have a speedy and full recovery. 

Please, continue to keep us updated.

 

Edited by member 07 Jun 2024 at 09:33  | Reason: Additional text

User
Posted 07 Jun 2024 at 08:16

Hi Everyone, 

To recap:

3 months post RP PSA: 0.31

2 weeks later : 0.42

2 weeks later : 0.35

2 days later : 0.39 ( confirmation test)

I had been hoping to get 0.5 to get PSMA scan and more accurate radiation. But feel I have been playing roulette with high risk factors ( Gleason 9/ extracapsular extension / seminal vesicle invasion) and today told my radiation oncologist I wanted to start hormone therapy and radiation now. I feel calmer now there is a plan.

Clinton

User
Posted 07 Jun 2024 at 08:23

Thanks for the update Clinton. I'm glad that you feel much more secure now that follow up treatment has been decided. Good luck mate.

User
Posted 07 Jun 2024 at 08:32
Thankyou Adrian
User
Posted 07 Jun 2024 at 08:36

Hi Clinton,

It’s a pity you’ve got to go through SRT having already had an RP,but that’s always a risk with surgery on borderline cases and at least you have a Plan B. You always feel better once a treatment plan is in place and I wish you all the best that they manage to zap anything that’s left.

Good luck,

Derek

User
Posted 07 Jun 2024 at 08:37

Thanks Derek

User
Posted 07 Jun 2024 at 09:53

Hi Everyone ,

Clinton was my username when I started on this forum . My name is Des and I actually live in Clinton. I will being using Des from here on!

Cheers Des

User
Posted 07 Jun 2024 at 11:01

Originally Posted by: Online Community Member
Clinton was my username when I started on this forum . My name is Des and I actually live in Clinton.

Hi Des.

I thought you'd picked Clinton after 'naughty Bill'😁

Edited by member 07 Jun 2024 at 20:03  | Reason: Typo

User
Posted 07 Jun 2024 at 22:04

Welcome Des from Clinton😊

User
Posted 10 Jun 2024 at 01:30

Hi Adrian.  Yes, the PSMA scan came back to show that the cancerous cells hadn’t spread but it DID indicate cells in the margin that wasn’t able to be removed. There had been a problem in the op due to adhesion of the gland onto surrounding tissue. 
The urology oncologist is very confident that the radiotherapy will be totally successful so happy days! 
I’ll keep you posted.  πŸ‘

 
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